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(Revised Schedule) Evaluation and development of immunotherapies with humanized mouse models
posted by HKU Pasteur Research Centre for HKU and Public
Event Type: Public Lecture/Forum/Seminar/Workshop/Conference/Symposium
Event Nature: Medical & Health Care

Event Details


Evaluation and development of immunotherapies with humanized mouse models

Dr Li Yan
Institut Pasteur Paris

Abstract: In recent decades, advances in our understanding of autoimmunity and cancer immunity dramatically improved immunotherapies against these diseases. Interestingly, effective antitumor immunity exploits the same mechanism underlying autoimmunity, whereas knowledge acquired from tumor immunotherapy can be applied to treat autoimmune diseases. To evaluate and develop novel immunotherapies, we developed models of human tumor and autoimmune diseases from human immune system (HIS) mice. In this talk, I will demonstrate the potential of HIS mice for biological drug discovery and as a preclinical platform to assess the efficacy and toxicity of immunotherapies.

Biosketch: Dr. Yan LI obtained his Ph.D from Singapore-MIT alliance program under the supervision of MIT Professor Jianzhu CHEN. He then moved to the Institut Pasteur in Paris where he is currently a postdoc in Prof. James DI SANTO’s laboratory. Dr. Li has over 10 years’ experience of developing humanized mouse models.


Date/Time17/04/2018 11:00-13:00
VenueHRI-S7, Rm 7-03, 7/Fl, HKJC Building for Interdisciplinary Research, 5 Sassoon Road

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