HKUEMS :: Event Details

Dental Research Seminar
posted by Faculty of Dentistry for HKU and Public
Event Type: Public Lecture/Forum/Seminar/Workshop/Conference/Symposium
Event Nature: Medical & Health Care

Event Details

Presenter: Yang Weifa, PhD Candidate (University no. 3030026357)

Title: Arecoline Induces DNA Mismatch Repair Deficiency and Its Relevance with Oral Carcinogenesis and Checkpoint Blockade Immunotherapy

Abstract:

PD-1/PD-L1 checkpoint blockade immunotherapy exhibits profound efficacy for advanced stage patients with oral cancer. However, the response rate to anti-PD-1 varies among patients and there is a lack of robust molecular predictors. To define a subgroup of oral cancer patients with high response rates to anti-PD-1 will not only improve personalized medicine, but also reduce social healthcare burden. Therefore, studies on defining a better candidate for checkpoint blockade immunotherapy among oral cancer patients are urgently needed. Recently, cancers harbor DNA mismatch repair deficiency (dMMR) are revealed to produce more cancer neoantigens, which confer a better response to immunotherapy. We have profiled the genetic landscapes of areca nut-induced oral cancer through high-throughput sequencing technology. Our preliminary data showed that compared with oral cancer induced by tobacco, the areca nut-induced oral cancer had prevalent dMMR signaling, which was positively correlated with microsatellite instability (MSI). These data promote us to hypothesize that dMMR may define a new candidate of areca nut-induced oral cancer for checkpoint blockade immunotherapy. In this proposal, we aim to 1) validate dMMR/MSI in areca nut-induced oral cancer, 2) elucidate the association of dMMR with tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 expression, and 3) investigate the therapeutic efficacy of PD-1 blockade in arecoline-induced oral cancer with dMMR in preclinical models. This proposal will potentially revolutionize personalized medicine in this life-threatening oral cancer.

Date/Time13/02/2018 12:45-13:15
VenueThe Lounge, 7/F, The Prince Philip Dental Hospital
LanguageEnglish

Registration Instruction

Registration is not required.

Contact Information

Should you have any enquiries, please feel free to contact Ms. Brenda Leung by email at leungpc@hku.hk