HKUEMS :: Event Details

Public Seminar of Physics RPg Student
posted by Department of Physics for HKU and Public
Event Type: Public Lecture/Forum/Seminar/Workshop/Conference/Symposium
Event Nature: Science & Technology

Event Details

Public Seminar of Physics RPg Student
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Novel Mesoporous Silica Nanoparticles with Tunable Size and Pore Structure as pH-sensitive Drug Delivery Vehicle for Cancer Therapy

Ms. Xiaoqing HU

Abstract:

A routine approach for cancer therapy in clinics is using chemotherapeutic agents including cisplatin, doxorubicin, camptothecin, amsacrine, etoposide, and teniposide. However, these chemotherapeutic agents have notorious side effects to humans and only limited effectiveness in killing carcinomatous cells. Curcumin, a relatively nontoxic natural product isolated from curcuma longa, has been widely used as a spice and coloring agent in food. It possesses potent anti-oxidative, anti-inflammatory and anti-tumor promoting activities. So far, curcumin has not yet been approved as a therapeutic agent on account of its low bioavailability, which is probably related to its extremely low aqueous solubility at acidic and neutral microenvironment. In this seminar, how to synthesize monodisperse mesoporous silica nanoparticles (MSN) with tunable size and pore structure in a facile way and in large scale will be discussed. Besides, how to conjugate MSN with curcumin to form an efficient pH-sensitive system which shows no cytotoxicity to normal cells after release of curcumin will also be discussed.

Anyone interested is welcome to attend.

Date/Time13/10/2017 14:00-14:30
VenueRm 522, 5/F, Chong Yuet Ming Physics Building, HKU
LanguageEnglish

Registration Instruction

Registration is not required.

Contact Information

Should you have any enquiries, please feel free to contact Ms Eva Wong by email at physdept@hku.hk or by phone at 2859 2360 or by fax at 2559 9152.