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William Mong Distinguished Lecture by Professor Chih-Ming Ho, March 1, 2017
posted by Faculty of Engineering for HKU and Public
Event Type: Public Lecture/Forum/Seminar/Workshop/Conference/Symposium
Event Nature: Architecture & Engineering

Event Details

WILLIAM MONG DISTINGUISHED LECTURE

Redefining the Drug Discovery Pathway - From Drug Candidate Search to Phenotypic Personalized Medicine (PPM)

Date: March 1, 2017 (Wednesday)

Time: 5:30pm – 6:30pm (Reception 5:00pm)

Venue: Lecture Theatre A, Chow Yei Ching Building, HKU

Speaker: Professor Chih-Ming Ho
Ben Rich-Lockheed Martin Chair Professor
University of California at Los Angeles

Abstract:
The current drug development roadmaps are on the order of 10-15 years and cost billions of dollars. The two fundamental challenges that impede drug development are: 1) Conventional approaches cannot pinpoint the best drug-dose combination from a large search space. 2) The current translation of drug doses from in vitro to in vivo test is by matching the PK or by weight scaling or by the maximum tolerated dose approach, which implicitly preclude optimization.

We have discovered that the drug-dose inputs are correlated with the phenotypic outputs with a Parabolic Response Surface (PRS). With a few calibration tests to determine to response surface, PRS can dictate the drugs and doses of a globally optimized drug combination at each stage of in vitro, preclinical, clinical test and even for a specific patient. PRS is an indication agnostic and mechanism free platform technology, which has been successfully demonstrated in about 30 diseases.

Biography:
Prof. Chih-Ming Ho received Ph.D. from The Johns Hopkins University. Currently, he is Distinguished Research Professor in UCLA School of Engineering. He served as UCLA Associate Vice Chancellor for Research from 2001 to 2005.

He is known for his researches in personalized medicine, micro/nano fluidics, and turbulence. In 1997, Prof. Ho was inducted as a member of the US National Academy of Engineering. In the next year, he was elected as an Academician of Academia Sinica. In 2014, Prof. Ho received Doctor of Engineering Honoris Causa from Hong Kong University of Science and Technology. Prof. Ho holds ten honorary chair professorships including the Einstein Professorship from Chinese Academy of Science. Prof. Ho was elected Fellow of the American Physical Society, American Association for the Advancement of Science, American Institute for Medical and Biological Engineering, American Institute of Aeronautics and Astronautics as well as 3M-Nano Society.

Date/Time01/03/2017 17:30-18:30
VenueLecture Theatre A, Chow Yei Ching Building, HKU
LanguageEnglish

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